Taking engineering for example, energy-saving design methods of clean air-conditioning system in hospital clean operating department are introduced, including optimizing architectural plane layout, reasonable collocating air-conditioning system, adopting secondary return air process, installing frequency conversion fan and reasonable establishing operation mode. 结合工程实例,介绍了医院洁净手术部净化空调系统的节能设计方法,包括优化手术部建筑平面布局、合理配置空调系统、采用二次回风处理、采用变频风机、合理制定运行方式。